Authors: *Taofik Olatunde SUNMONU, Oyelola Bukoye Oloyede
Journal of Applied Biosdences (2009), VoL 13: 720 – 725.
ISSN 1997 – 5902: www.biosdences.elewa.org –
Abstract
Objective: To study changes in selected liver enzymes of albino rats fed on diet formulated with catfish that ‘N8re ex~ for 30 days to water polluted with crude oil.
Methodology and results: One hundred and twenty (120) catfish (Clarias gariepinus) in six groups
of 20 catfish each were held for 30 h in water having five different concentrations of crude oil (0.1, 0.25, 0.5, 0.75 and 1% vlv). The catfish in the Control group were held in un-polluted borehore water. After 30 h, the catfish were harvested and used to formulate diet. Albino rats (n = 60) in six group of 10 rats each were fed on the formulated diet for a period of 30 days. The control rats were fed on diet containing catfish cultured in cultured in borehole water those in groups of two to six were fed on diets containing catfish exposed to the various concentrations of crude oil. In comparison with the control, a significant reduction (p<0.05) in the activities of aspartate transaminase (AST), alaline transaminase (ALT), alkaline phosphate (ALP) and gama glutmyl transferase (GGT) was observed as the concentration of crude oil in the diet increased. Conversely, the activities of these enzymes in the serum of treated albino rats increased significantly (p<0.05) when compared with the control.
Conclusion and application of findings: The data obtained suggests a possible adverse effect of crude oil albino rats, as manifested by changes in liver enzymes. This demonstrates the adverse impact of crude oil intoxication during oil spillage and pollution, a common occurrence life and animals.